Evo-Devo and the Master Development Program George Parris

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Evo-Devo and the Master Development Program  by  George Parris

Evo-Devo and the Master Development Program by George Parris
| Kindle Edition | PDF, EPUB, FB2, DjVu, talking book, mp3, ZIP | 144 pages | ISBN: | 10.45 Mb

This manuscript summarizes an unproven and highly speculative hypothesis that I have formulated and partially published concerning the mechanics of how differentiation of cells occurs and how complex, multi-cellular organisms develop. The hypothesisMoreThis manuscript summarizes an unproven and highly speculative hypothesis that I have formulated and partially published concerning the mechanics of how differentiation of cells occurs and how complex, multi-cellular organisms develop.

The hypothesis is only supported by circumstantial evidence, which is consistent with the proposed mechanism, but does not prove the mechanism in any way. I call this hypothesis the Master Development Program (MDP). Very briefly, the program is a sequence of transcribable DNA sequences that regulate the expression of protein-coding genes in each generation of the cell clone through non-coding RNA transcripts (called nuclear messenger RNAs, nmRNAs, which include all the many classes of non-coding RNAs that have been observed). The MDP is proposed to evolve through terminal additions and to be located in the pericentromeric heterochromatin (alpha satellite) DNA.

The manuscript summarizes how I came to concoct the hypothesis and provides a conventional review of the current state of our understanding of differentiation and reprogramming of cells in complex, multi-cellular organisms. I have tried to make the general ideas understandable by people with a general interest in biology and provide enough substantive information to make it worthwhile reading for researchers engaged in evolutionary developmental biology (EVO-DEVO) and genome regulation.

I will be happy to receive criticism of the hypothesis...that is why you make hypotheses...to prove they are wrong. If you have proof, please let me know so that I can revise my thinking.



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